OpenEvidence

Founded

2021

Funding

$210M Series B (2025)

OpenEvidence: AI Medical Knowledge Platform for Clinicians

OpenEvidence is an AI-driven medical knowledge platform designed for clinicians to rapidly find, synthesize, and cite peer‑reviewed evidence during patient care. It aggregates top clinical sources (NEJM, JAMA, PubMed, and major guidelines) and delivers natural‑language answers with inline citations and auditable source trails across web and mobile.

Website: [OpenEvidence](https://www.openevidence.com/)

About the company: [About OpenEvidence](https://www.openevidence.com/about)

What OpenEvidence Does

Provides a citation‑first agent that answers clinical questions in plain English with clickable references and source passages.

Aggregates and ranks evidence across journals, PubMed, and guideline repositories to surface the most relevant literature fast.

Maintains an audit trail, lets users drill into abstracts and PDFs, and flags uncertainty when evidence is weak.

Core Capabilities

Evidence synthesis with inline citations and source inspection

Ranked retrieval across NEJM, JAMA Network content, PubMed, and major guidelines

Differential diagnosis support, therapy comparisons, and dosing details with references

Uncertainty and evidence‑strength signaling to mitigate overconfidence

Web, iOS, and Android access for point‑of‑care and on‑the‑go use

Download and learn more via [OpenEvidence](https://www.openevidence.com/).

Sources and Coverage

Peer‑reviewed journals and clinical repositories including NEJM, JAMA Network content, PubMed, and major guidelines

Emphasis on freshness, speed, and breadth of primary literature compared with traditional point‑of‑care references

NEJM and JAMA partnerships:

[OpenEvidence + NEJM Group](https://www.openevidence.com/announcements/openevidence-and-nejm)

JAMA Network content coverage noted in product materials

Platform, Security, and Enterprise

Platforms: Web, iOS, and Android (mobile apps highlighted on the site)

Enterprise features for health systems:

Single Sign‑On (SSO)

PHI‑safe use with BAA pathways

Workflow integrations via Microsoft collaboration

Microsoft collaboration announcement: [Bringing clinical evidence and guidelines into enterprise clinician workflows](https://www.openevidence.com/announcements/openevidence-collaborates-with-microsoft-to-expand-ai-leadership-in-healthcare-bringing-clinical-evidence-and-guidelines-to-enterprise-clinician-workflows)

Who It’s For

Physicians, residents, PAs, NPs, pharmacists, and clinical librarians

Academic medical centers and hospital systems needing enterprise controls and integration

Clinicians who want rapid literature synthesis with verifiable source links

Common Clinical Use Cases

Rapid evidence checks at the bedside with citations

Building and comparing differentials

Pulling dosing, contraindications, and guideline‑directed therapy with links to the primary source

Preparing consult notes with cited evidence passages

Teaching, journal club prep, and staying current with high‑impact journals

How It Compares

Versus search tools (e.g., PubMed): adds ranked retrieval across sources, automatic synthesis, and inline citations.

Versus traditional reference products: emphasizes freshness, speed, and breadth of the primary literature.

Tradeoffs cited by users: verify claims and watch for occasional hallucinations when evidence is thin.

Pricing and Access

Free tier for individual clinicians; mobile apps are free to download

Enterprise licensing for organizations, with SSO/BAA and integrations

Learn more on the [OpenEvidence site](https://www.openevidence.com/)

Partnerships, Claims, and Funding

NEJM Group and JAMA Network content collaborations: [NEJM partnership](https://www.openevidence.com/announcements/openevidence-and-nejm)

Microsoft enterprise collaboration: [Announcement](https://www.openevidence.com/announcements/openevidence-collaborates-with-microsoft-to-expand-ai-leadership-in-healthcare-bringing-clinical-evidence-and-guidelines-to-enterprise-clinician-workflows)

Notable claim: first AI to score 100% on the USMLE (press release): [USMLE announcement](https://www.openevidence.com/announcements/openevidence-creates-the-first-ai-in-history-to-score-a-perfect-100percent-on-the-united-states-medical-licensing-examination-usmle)

Funding coverage and investor interest:

[GV profile](https://www.gv.com/news/openevidence-ai-doctors)

[FierceHealthcare coverage](https://www.fiercehealthcare.com/ai-and-machine-learning/openevidence-raises-210m-unveils-ai-agents-built-advanced-medical-research)

Clinical Evaluation

Peer‑reviewed evaluation of OpenEvidence for clinical questions: [NIH/PMC article](https://pmc.ncbi.nlm.nih.gov/articles/PMC12033599/)

User Sentiment Snapshot

Pros

Fast path to relevant papers and guidelines with source links:

[r/emergencymedicine](https://www.reddit.com/r/emergencymedicine/comments/1eoafxh/how_reliable_is_openevidencecom/): “gets me to some solid articles around a question very quickly”

Useful to kickstart differentials and planning:

[r/physicianassistant](https://www.reddit.com/r/physicianassistant/comments/1k2lq47/what_do_you_use_open_evidence_for/): “use it for differentials prior to seeing patients… helped me become more independent”

Strong starting point for difficult cases (verify afterward):

[r/Psychiatry](https://www.reddit.com/r/Psychiatry/comments/1fulw6k/open_evidence_accuracyusefulness/): “great place to start research or get some ideas… always fact check”

Growing awareness/adoption:

[r/Residency](https://www.reddit.com/r/Residency/comments/1l10gec/hi_colleagues_i_just_been_wondering_does_anyone/): “All the cool kids seem to use OpenEvidence”

Cons

Occasional hallucinations; verify claims:

[r/Residency](https://www.reddit.com/r/Residency/comments/1lt5nzj/open_evidence/): “Open Evidence is great. Just be careful because it can still hallucinate”

Concerns about fabricated or weak references when evidence is thin:

[r/hospitalist](https://www.reddit.com/r/hospitalist/comments/1je4ria/open_evidence/): “fabricates evidence with poor references”

Some users find answers generic or need more frictionless citations:

[r/physicianassistant](https://www.reddit.com/r/physicianassistant/comments/1lz87o4/alternatives_to_openevidence/): “generic answers… citations are always for papers I need to plug back in…”

Not a full replacement for point‑of‑care references in some workflows:

[r/Residency](https://www.reddit.com/r/Residency/comments/1lt5nzj/open_evidence/): “UpToDate is a better place to go overall”

Quick Facts

Company: OpenEvidence

Category: AI medical knowledge platform with a citation‑first agent

Core sources: NEJM, JAMA Network content, PubMed, major guidelines

Platforms: Web, iOS, Android

Users: Verified clinicians; enterprise deployments via health systems

Security: Enterprise path with SSO and BAA for PHI‑safe workflows

Free trial: Yes — free tier available; enterprise features require a paid agreement

For announcements and product updates, visit the [OpenEvidence Newsroom](https://www.openevidence.com/announcements/).

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